{"id":427,"date":"2025-06-18T13:56:58","date_gmt":"2025-06-18T13:56:58","guid":{"rendered":"http:\/\/tcn.nl\/?p=427"},"modified":"2025-07-21T10:23:00","modified_gmt":"2025-07-21T10:23:00","slug":"cocukluk-cagi-kanseri-atlatanlarda-agiz-sagligi-ve-dis-gelisimine-uzun-vadeli-etkiler","status":"publish","type":"post","link":"https:\/\/tcn.nl\/tr\/blog\/lange-termijneffecten-op-de-mondgezondheid-en-gebitsontwikkeling-bij-overlevenden-van-kinderkanker\/","title":{"rendered":"\u00c7ocukluk \u00e7a\u011f\u0131 kanseri atlatanlarda a\u011f\u0131z sa\u011fl\u0131\u011f\u0131 ve di\u015f geli\u015fimine uzun vadeli etkiler"},"content":{"rendered":"<p><strong>Di\u015f hekimi Kim Vlaanderen, \u00e7ocukluk \u00e7a\u011f\u0131 kanseri atlatanlarda a\u011f\u0131z sa\u011fl\u0131\u011f\u0131 ve di\u015f geli\u015fimini ara\u015ft\u0131rd\u0131. \u00dc\u00e7 merkezden biri olan UMC, VU lokasyonunda toplanan sonu\u00e7lar\u0131 a\u00e7\u0131klad\u0131. \u00dc\u00e7 merkezden elde edilen sonu\u00e7lar, kat\u0131l\u0131mc\u0131lar\u0131n ,31&#039;inin en az bir di\u015f geli\u015fim bozuklu\u011funa sahip oldu\u011funu g\u00f6stermektedir. Bu \u00e7al\u0131\u015fma Cancers dergisinde yay\u0131nlanm\u0131\u015ft\u0131r.<\/strong><\/p>\n<p>Bu kesitsel \u00e7al\u0131\u015fma, DCCSS (Hollanda \u00c7ocukluk \u00c7a\u011f\u0131 Kanserinden Kurtulanlar \u00c7al\u0131\u015fmas\u0131) LATER (LATER TERmijn) \u00c7al\u0131\u015fmas\u0131n\u0131n bir par\u00e7as\u0131d\u0131r. Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, tan\u0131 konulduktan 5 y\u0131ldan uzun s\u00fcre sonra \u00e7ocukluk \u00e7a\u011f\u0131 kanserinden kurtulanlarda di\u015f geli\u015fim anormalliklerinin ve a\u011f\u0131z sa\u011fl\u0131\u011f\u0131 sorunlar\u0131n\u0131n yayg\u0131nl\u0131\u011f\u0131n\u0131 ve risk fakt\u00f6rlerini belirlemektir.<\/p>\n<p>Kat\u0131l\u0131mc\u0131lar, 1963 ile 2001 y\u0131llar\u0131 aras\u0131nda Hollanda&#039;daki yedi \u00e7ocuk onkoloji merkezinden birinde, 0 ile 17 ya\u015flar\u0131 aras\u0131nda malignite tan\u0131s\u0131 konulmu\u015fsa \u00e7al\u0131\u015fmaya dahil edildi. Veriler, \u015eubat 2016 ile Mart 2020 tarihleri aras\u0131nda Hollanda&#039;daki yedi DCCSS LATER poliklini\u011finden \u00fc\u00e7\u00fcnde (LUMC, PMC, UMC VU lokasyonu) topland\u0131. Tez, UMC VU lokasyonunda toplanan sonu\u00e7lar\u0131 a\u00e7\u0131klam\u0131\u015ft\u0131r. Bu \u00f6zet, \u015fimdi a\u00e7\u0131klanan \u015fekilde, \u00fc\u00e7 merkezin t\u00fcm\u00fcn\u00fcn sonu\u00e7lar\u0131n\u0131 kapsamaktad\u0131r. <a href=\"https:\/\/www.mdpi.com\/2072-6694\/13\/21\/5264\" target=\"_blank\" rel=\"noopener\">yay\u0131nlanan makale<\/a> (Stolze, J.; Vlaanderen, KCE; Holtbach, FCED; Teepen, JC; Kremer, LCM; Loonen, JJ; ve di\u011ferleri. \u00c7ocukluk \u00c7a\u011f\u0131 Kanser Tedavisinin Di\u015f Yap\u0131s\u0131 ve A\u011f\u0131z Sa\u011fl\u0131\u011f\u0131 \u00dczerindeki Uzun Vadeli Etkileri: DCCSS LATER 2 \u00c7al\u0131\u015fmas\u0131ndan Di\u015f Hekimi Anketi. Cancers 2021, 13, 5264).<\/p>\n<h3 class=\"fw-semibold\">Ara\u015ft\u0131rma sonu\u00e7lar\u0131<\/h3>\n<p>\u00c7al\u0131\u015fma, a\u015fa\u011f\u0131daki kaynaklardan elde edilen ara\u015ft\u0131rma verilerini i\u00e7ermektedir. <strong>154 kurtulan<\/strong> \u00c7ocukluk \u00e7a\u011f\u0131 kanseri olan ve a\u011f\u0131z verilerine ili\u015fkin bilgileri di\u015f hekimlerinden al\u0131nan (71,3%) kat\u0131l\u0131mc\u0131lar incelenmi\u015ftir. Sonu\u00e7lar, kat\u0131l\u0131mc\u0131lar\u0131n 36,3%&#039;sinde en az bir di\u015f geli\u015fim bozuklu\u011fu oldu\u011funu g\u00f6stermektedir. En yayg\u0131n olanlar k\u0131salm\u0131\u015f k\u00f6kler (14,6%), agenez (14,3%) ve mikrodonti (13,6%) idi. Kat\u0131l\u0131mc\u0131lar\u0131n 19,9%&#039;sinden fazlas\u0131nda alt veya \u00fcst \u00e7ene premolarlar\u0131 geli\u015fim bozuklu\u011fundan etkilenmi\u015fti. En az bir geli\u015fim bozuklu\u011fu i\u00e7in risk fakt\u00f6rleri, tan\u0131 an\u0131ndaki daha gen\u00e7 ya\u015f (&lt;3 ya\u015fa kar\u015f\u0131 &gt;5 ya\u015f, 2 kat daha y\u00fcksek risk) ve alkilleyici ajanlar kullan\u0131larak kemoterapi ile daha y\u00fcksek k\u00fcm\u00fclatif doz tedavisi (\u226510.000 mg\/m\u00b2, 2,6 kat daha y\u00fcksek risk) idi. Agenez esas olarak ikinci premolarlar\u0131, mikrodonti ise esas olarak birinci premolarlar\u0131 etkilemi\u015ftir. K\u0131salm\u0131\u015f k\u00f6kler ve hipomineralizasyon t\u00fcm di\u015fleri etkilemi\u015ftir. Te\u015fhis an\u0131nda 3 ya\u015f\u0131n alt\u0131nda olan hayatta kalanlarda, di\u015f agenezisi, mikrodonti, konik di\u015fler ve kal\u0131c\u0131 s\u00fct di\u015flerinin g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131, te\u015fhis an\u0131nda 3 ya\u015f\u0131n \u00fczerinde olan hayatta kalanlara k\u0131yasla anlaml\u0131 derecede daha y\u00fcksekti.<\/p>\n<p>Bu \u00e7al\u0131\u015fmadan elde edilen bilgiler di\u015f hekimleri, di\u015f hijyenistleri ve \u00e7ocuk onkologlar\u0131 i\u00e7in hayati \u00f6nem ta\u015f\u0131makta olup, \u00e7ocukluk \u00e7a\u011f\u0131 kanseri atlatanlarda a\u011f\u0131z sa\u011fl\u0131\u011f\u0131 sorunlar\u0131n\u0131n erken te\u015fhisini, \u00f6nlenmesini ve di\u015f bak\u0131m\u0131n\u0131 iyile\u015ftirmelerine yard\u0131mc\u0131 olmaktad\u0131r.<\/p>\n<p><strong>Yazan: Kim Vlaanderen, di\u015f hekimi.<\/strong> Bu ara\u015ft\u0131rmas\u0131yla NVvK-Elmex\u00ae tez \u00f6d\u00fcl\u00fc yar\u0131\u015fmas\u0131nda ikincilik \u00f6d\u00fcl\u00fcn\u00fc kazand\u0131.<\/p>","protected":false},"excerpt":{"rendered":"<p>Tandarts Kim Vlaanderen onderzocht de mondgezondheid en gebitsontwikkeling bij overlevenden van kinderkanker. Zij beschreef de resultaten die verzameld werden in \u00e9\u00e9n van de drie ge\u00efncludeerde centra, het UMC, locatie VU. Uit de resultaten van de drie centra blijkt dat 36,3% van de deelnemers ten minste \u00e9\u00e9n tandheelkundige ontwikkelingsstoornis had. Dit onderzoek is gepubliceerd in Cancers. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1269,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-427","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-niet-gecategoriseerd"],"acf":[],"_links":{"self":[{"href":"https:\/\/tcn.nl\/tr\/wp-json\/wp\/v2\/posts\/427","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tcn.nl\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tcn.nl\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tcn.nl\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tcn.nl\/tr\/wp-json\/wp\/v2\/comments?post=427"}],"version-history":[{"count":5,"href":"https:\/\/tcn.nl\/tr\/wp-json\/wp\/v2\/posts\/427\/revisions"}],"predecessor-version":[{"id":1050,"href":"https:\/\/tcn.nl\/tr\/wp-json\/wp\/v2\/posts\/427\/revisions\/1050"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tcn.nl\/tr\/wp-json\/wp\/v2\/media\/1269"}],"wp:attachment":[{"href":"https:\/\/tcn.nl\/tr\/wp-json\/wp\/v2\/media?parent=427"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tcn.nl\/tr\/wp-json\/wp\/v2\/categories?post=427"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tcn.nl\/tr\/wp-json\/wp\/v2\/tags?post=427"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}